Infective Endocarditis

Infective endocarditis (IE) is defined as an infection of the endocardial surface of the heart by Enterococci, which may include one or more heart valves, the mural endocardium, or a septal defect. Its intracardiac effects include severe valvular insufficiency, which may lead to intractable congestive heart failure and myocardial abscesses. If left untreated, IE is generally fatal. Market volume is $800m (2015) with no specific registered drugs in market. OxAG lead compound´s efficacy against Enterococci with good toxic profile might offer strong first in class capabilities to treat infections caused by Enterococci.