Infective endocarditis (IE) is defined as an infection of the endocardial surface of the heart by Enterococci, which may include one or more heart valves, the mural endocardium, or a septal defect. Its intracardiac effects include severe valvular insufficiency, which may lead to intractable congestive heart failure and myocardial abscesses. If left untreated, IE is generally fatal. Market volume is $800m (2015) with no specific registered drugs in market. OxAG lead compound´s efficacy against Enterococci with good toxic profile might offer strong first in class capabilities to treat infections caused by Enterococci.