The Oxford Antibiotic Group uses its proprietary Logi-bioticTM profiling protocol to identify novel natural compounds which can be modulated to generate novel bioactive lead compounds for clinical development. The Logi-biotic approach uses various methods such as data mining and tailored med-chem programs. Data mining identifies antibacterial natural products of interest, and this is followed by rapid chemical synthesis of derivatives, a process that overall leads to a faster identification of new classes of structurally novel antibiotics. An alternative proprietary strategy employed by OxAG is to create compound libraries by chemical hybridization, combining chemical structures of interest.

Both methods allow OxAG to create large sets of structurally different chemical compounds which can be used in biological screenings.